Olaparib
Consider dose interruption or dose reduction to manage adverse reactions. Recommended dose reduction: 200 mg (four 50-mg capsules) PO BID. If a further final dose reduction is required, then reduce to 100 mg (two 50-mg capsules) PO BID。
PARP inhibitors work by blocking the action of poly (ADP-ribose) polymerase, an enzymeA protein that speeds up the process of chemical reactions in the body without becoming altered in the process. Almost every biological process is driven by the activity of enzymes. Without enzyme catalysts, the complex reactions that build and break down cell parts would not happen at a rate compatible with life. Enzyme names usually describe the reaction that is being catalyzed and all of them end in -ase. that helps repair DNAAbbreviation for deoxyribonucleic acid. Composed of very long strings of nucleotides, which are abbreviated as A, C, G and T. DNA is the storage form of our genetic material. All of the instructions for the production of proteins are encoded in our DNA. . In certain tumor cells, such as those from BRCA mutation carriers, blocking this enzyme can lead to cell death. Women who carry BRCA mutations are at a higher risk of developing some types of cancer, including ovarian and breast cancers.
Common side effects include nausea and vomiting，fatigue，diarrhea，indigestion，headache，appetite problems，common cold-like symptoms，cough ，rash，pain in joints, muscles, bones, back, and abdomen。
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