Cabazitaxel
Jevtana is given through a vein (intravenously, IV). There is no pill form of Jevtana. You will take a corticosteroid pill, prednisone, twice a day, every day while being treated with Jevtana. You will be given pre-medications about 30 minutes prior to each Jevtana infusion. This is to decrease the risk of having a reaction to the Jevtana。
Jevtana is a microtubuleA cable-like structure that is part of the cytoskeleton composed of long chains of the protein tubulin. Microtubules give a cell shape, aid in cellular motility and are very important in cell division. Microtubules grow and shrink depending on the needs of the cell. The anticancer drugs taxol, vincristine and vinblastine (and their derivatives) all work by interfering with the function of microtubules. inhibitor. Microtubules are essential to cell division, and taxanes, such as Jevtana, stabilize a particular type of proteinOne of the four basic types of biomolecule. Proteins are polymers made up of strings of amino acids. Proteins serve many functions in organisms including transport of molecules, structure, cell adhesion and as signaling molecules such as hormones. Many transcription factors, including p53 and Rb are proteins. in the microtubule, thereby inhibiting the process of cell division. This prevention of cell/division/growth ultimately results in cell death.
Side effects include black, tarry stools，bleeding gums，bloating or swelling of the face, arms, hands, lower legs, or feet，blood in the urine or stools，burning/numbness/tingling/painful sensations，chest pain，chills，cough，difficult or labored breathing，difficult or painful urination，fever，lower back or side pain，pale skin，pinpoint red spots on the skin，rapid weight gain，sore throat，sores/ulcers/white spots on the lips or in the mouth，swollen glands，tightness in the chest，unsteadiness or awkwardness，unusual bleeding or bruising，unusual tiredness or weakness，unusual weight gain or loss，weakness in the arms, hands, legs, or feet。
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