Oncogenes and Tumor Supressors

Human chromosomes

1976 - Harold E. Varmus and J. Michael Bishop discovers the first cellular oncogene, src. This is the same gene carried by the virus originally described by Peyton Rous.

1986 - Stephen H. Friend et al. isolates the first tumor suppressor gene, Rb (for retinoblastoma). This gene was also one of the first associated with an inherited (familial) form of cancer.1 2

  • 1Marx, Jean L. "Cancer Gene Research Wins Medicine Nobel." Science. 246 (1989):326-327. [PUBMED]
  • 2Friend, Stephen H., et al. "A Human DNA Segment with Properties of the Gene that Predisposes to Retinoblastoma and Osteosarcoma." Nature. 323 (1986): 643-646. [PUBMED]