Environmental Protection Agency (EPA) no longer lists saccharine as hazardous substance.

For over 20 years, the role of saccharin has been a contentious subject in discussions of food and human health. This artificial sweetener is used in many popular diet foods and drinks due to its high level of sweetness (~300x sweeter than sugar) and the fact that it does not contain any calories. In the years since its introduction, some people have suggested that saccharin is capable of causing cancer.  This month, in response to the results of a review of public health information regarding saccharin, the EPA has removed the sugar substitute from its list of hazardous substances.