Granisetron

Diagram of the molecular structure of Granisetron
Brand name: Sancuso®
IUPAC: 1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]nonan-7-yl)indazole-3-carboxamide
FDA approval: Yes
Manufacturer Link
Usage:

Granisetron is used to the prevent nausea and vomiting associated with cytotoxicHaving the ability to kill a cell. Many chemotherapy drugs are cytotoxic, as is radiation. Cells of our immune system also have the ability to recognize and kill certain cells, including cancer cells. effects of chemotherapyTreatment of cancer patients with anticancer drugs. Commonly called 'chemo'. These drugs work by attacking cell growth or division. Often these agents are used in combination to take advantage of their different modes of attack on cell division.. Granisetron is administered in pill form or as in injection. 1

Mechanism:

Granisetron is a 5-HT3 receptor antagonist, which is used to inhibit nauseous responses caused by chemotherapyTreatment of cancer patients with anticancer drugs. Commonly called 'chemo'. These drugs work by attacking cell growth or division. Often these agents are used in combination to take advantage of their different modes of attack on cell division.. It has a strong affinity for this receptor and little for any other type and by blocking this receptor, granisetron prevents the the vomiting reflex.1

The diagram below shows the 3D molecular structure for Granisetron. 

Side effects:

The most common side effects associated with the use of Granisetron include headache, stomach pain, heartburn, constipation and trouble sleeping.1

  • 1. Sancuso. 2016. http://www.sancuso.com/patient/understanding-cinv/index.html
  • 2.a. b. Granisetron. MedlinePlus. https://medlineplus.gov/druginfo/meds/a601211.html