Anastrozole

Anastrazole is used to treat postmenopausal women with estrogen receptorA protein located within cells that binds estrogen. The protein:estrogen complex then binds to DNA to increase the transcription of certain genes, and therefore is a type of transcription factor. The estrogen receptor is the target of the anticancer drug tamoxifen. By binding to the estrogen receptor tamoxifen blocks the growth promoting effects of the hormone. May be abbreviated as ER. positive breast cancer. This drug is often given in conjunction with other drugs such as tamoxifen in early stage cancers. Anastrazole is taken in tablet form usually just once a day.
Anastrazole (Arimidex®) lowers estrogenA steroid sex hormone. Estrogen's structure is closely related to cholesterol. Produced by the ovaries, estrogen has effects on the reproductive, cardiovascular and skeletal systems. Estrogen is also a growth factor for some types of cells, including breast cells. Inhibitors of estrogen function such as tamoxifen and arimidex are used to block the growth effects of estrogen. See also, estrogen receptor. levels in the body, particularly the form of estrogen known as estradiol. Many breast tumors display estrogen receptors on cell surfaces. When these receptors are bound to estrogen it is thought that cell growth and thus tumor growth are stimulated. Anastrazole inhibits the enzymeA protein that speeds up the process of chemical reactions in the body without becoming altered in the process. Almost every biological process is driven by the activity of enzymes. Without enzyme catalysts, the complex reactions that build and break down cell parts would not happen at a rate compatible with life. Enzyme names usually describe the reaction that is being catalyzed and all of them end in -ase. aromatase, which aids in the production of estrogen. By inhibiting estrogen synthesis anastrazole is able to lower estrogen levels in the body which can result in a decrease in tumor size or a delay in tumor growth.
The structure above shows the 3D conformer Anastrozole.
Common side effects include hot flashes, nausea, decreased energy, back and bone pain, joint pain or stiffness. Side effects may differ from those listed above if anastrazole is being taken with other medications. 1
- 1. Arimidex.. Prescribing Information. AstraZeneca Pharmaceuticals. March, 2016. [http://www.arimidex.com]