Nilutamide
Nilutamide is used to treat stage D2 metastaticThe term for a cancer that has spread beyond its point of origin. Metastatic disease is responsible for the majority of cancer deaths. prostate cancer in combination with treatments like surgical castration.1
Nilutamide competes with male sex hormones (androgens) for the binding to androgen receptors, and blocks the activity of the male sex hormoneA chemical produced by cells that alters the activity of other cells. The chemicals may be lipids, such as testosterone and estrogen or proteins like insulin. Hormones may act at locations far from their site of origin. Estrogen, for example, is produced primarily by cells in the ovaries but acts on cells in the breast and elsewhere. testosteroneTestosterone is the main male sex hormone and is responsible for the generation of the secondary sex characteristics. The hormone is produced in male testes and is normally found to a much lesser extent in females.. Testosterone can stimulate the growth of both normal and malignantA tumor that has invaded neighboring tissue. prostate cells. The drug blocks the effects of the hormones on cancer cells, removing the growth stimulus. Because of the way it works, nilutamide is called an 'androgen antagonist', a type of hormonal cancer treatment.1
The molecular structure above is the 3D conformer Nilutamide.
Common side effects include constipation, dizziness, hot flashes, and visual changes (in up to 60% of patients). If you experience yellowing of the skin or eyes, nausea, vomiting, stomach pain, pain in the upper right part of the stomach, extreme tiredness, loss of appetite, flu-like symptoms, or dark urine call your doctor immediately as these side effects may be serious. Nilutamide may also cause lung disease so tell your doctor if you have ever had any type of lung disease. If you experience shortness of breath, cough, chest pain, or fever, stop taking nilutamide and call your doctor immediately.1
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