Teniposide
Vumon is a prescription medication used with other chemotherapyTreatment of cancer patients with anticancer drugs. Commonly called 'chemo'. These drugs work by attacking cell growth or division. Often these agents are used in combination to take advantage of their different modes of attack on cell division. drugs to treat acute lymphocytic leukemiaA cancer affecting the cells that develop into white or red blood cells. Both of these cell types originate from stem cells in bone marrow. Red blood cells function to carry oxygen to our tissues and the white cells (leukocytes) are part of our immune system. The cancerous cells often accumulate in the blood. (ALL) in children. It is used in when the you has not improved with other medications or when ALL has worsened. ALL a type of cancer of the white blood cells.
Teniposide is a phase-specific cytotoxicHaving the ability to kill a cell. Many chemotherapy drugs are cytotoxic, as is radiation. Cells of our immune system also have the ability to recognize and kill certain cells, including cancer cells. drug, acting in the late S or early G2 phase of the cell cycle, thus preventing cells from entering mitosisThe portion of the cell cycle (M stage) during which a cell divides into two (usually identical) daughter cells.. Teniposide causes dose-dependent single- and double-stranded breaks in DNAAbbreviation for deoxyribonucleic acid. Composed of very long strings of nucleotides, which are abbreviated as A, C, G and T. DNA is the storage form of our genetic material. All of the instructions for the production of proteins are encoded in our DNA. and DNA-proteinOne of the four basic types of biomolecule. Proteins are polymers made up of strings of amino acids. Proteins serve many functions in organisms including transport of molecules, structure, cell adhesion and as signaling molecules such as hormones. Many transcription factors, including p53 and Rb are proteins. cross-links. The mechanism of action appears to be related to the inhibition of type II topoisomeraseAn enzyme that cuts double stranded DNA to reduce tension created during local unwinding of the helix. Unwinding of DNA is required for transcription, translation and replication. Chemotherapy drugs such as topotecan and etoposide (VP-16) inhibit topoisomerases. activity since teniposide does not intercalate into DNA or bind strongly to DNA. The cytotoxic effects of teniposide are related to the relative number of double-stranded DNA breaks produced in cells, which are a reflection of the stabilization of a topoisomerase II-DNA intermediate. Teniposide has a broad spectrum of in vivo antitumor activity against murine tumors, including hematologic malignancies and various solid tumors. Notably, teniposide is active against sublines of certain murine leukemias with acquired resistance to cisplatin, doxorubicin, amsacrine, daunorubicin, mitoxantrone, or vincristine.
Common side effects of Vumon include: low blood cell counts, sores and inflammationA reaction to tissue damage or invasion. Small blood vessels become leaky, leading to redness and swelling. Cells of the immune system migrate to the area and can release chemicals and proteins that cause damage to the structures/cells nearby. of the mouth, diarrhea, nausea, vomiting, infection, hair loss, bleeding, rash, and fever.
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