Abemaciclib
Verzenio is a prescription medicine used:
- In combination with fulvestrant to treat women with hormoneA chemical produced by cells that alters the activity of other cells. The chemicals may be lipids, such as testosterone and estrogen or proteins like insulin. Hormones may act at locations far from their site of origin. Estrogen, for example, is produced primarily by cells in the ovaries but acts on cells in the breast and elsewhere. receptor (HR)–positive, human epidermal growth factorA substance that stimulates cell division. Growth factors are usually small proteins or steroid hormones. They may be secreted by the same cells on which they act or by cells that reside in a different part of the body than the target cells. Some examples of growth factors include estrogen, a growth factor for breast cells, and VEGF, a growth factor that causes the development of blood vessels. Several different anti-cancer treatments are designed to inhibit the activity of growth factors. receptor 2 (HER2)–negative advanced breast cancer or breast cancer that has spread to other parts of the body (metastaticThe term for a cancer that has spread beyond its point of origin. Metastatic disease is responsible for the majority of cancer deaths.), whose disease has progressed after hormonal therapy.
- Alone to treat adults with HR–positive, HER2–negative advanced breast cancer or metastatic breast cancer whose disease has progressed after hormonal therapy and prior chemotherapyTreatment of cancer patients with anticancer drugs. Commonly called 'chemo'. These drugs work by attacking cell growth or division. Often these agents are used in combination to take advantage of their different modes of attack on cell division..
An orally available cyclin-dependent kinaseAn enzyme that adds phosphate groups to another molecule. Many key proteins controlling gene expression are kinase targets. Addition of a phosphate group to a protein can alter the activity of the protein and are often used as molecular on/off switches. For example, the retinoblastoma tumor suppressor gene is 'off' when phosphate groups are added to the protein at specific locations. Removal of the phosphate groups turns the protein 'on'. Enzymes that remove phosphate groups are known as phosphatases. Note that all enzymes, regardless of function, end in ASE (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. Abemaciclib specifically inhibits CDK4 and 6, thereby inhibiting retinoblastomaA cancer of the retina. Found most often in small children; this disease has been linked to the inheritance of mutated copies of the Rb tumor suppressor gene. For more information, see the entries on Rb and Tumor Suppressor. (RbA tumor suppressor. The Rb gene is mutated in many different cancers but was initially described due to its role in the development of an eye cancer, retinoblastoma, which usually strikes young children. The protein product of the gene is a transcription factor that controls the expression of genes important in driving cells into the division process.) proteinOne of the four basic types of biomolecule. Proteins are polymers made up of strings of amino acids. Proteins serve many functions in organisms including transport of molecules, structure, cell adhesion and as signaling molecules such as hormones. Many transcription factors, including p53 and Rb are proteins. phosphorylationThe addition of a phosphate group to a metabolic intermediate or to a protein. The addition or removal (dephosphorylation) of phosphate groups acts as a biological on/off switch for many processes. Addition or removal of a phosphate group can activate/inactivate an enzyme and control processes such as cell division. Enyzmes that add phosphate groups are termed kinases and those that remove phosphate groups are called phosphatases. in early G1. 1
The most common side effects of Verzenio include: nausea, infections, decreased appetite, headache, abdominal pain, tiredness and vomiting.
The most common changes to blood tests were low red blood cell count (anemia), low white blood cell counts (leukopenia) and low platelet count (thrombocytopenia).
- 1. https://hemonc.org/wiki/Abemaciclib_(Verzenio)
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