Dacarbazine
Malignancies for which dacarbazine is used include: MetastaticThe term for a cancer that has spread beyond its point of origin. Metastatic disease is responsible for the majority of cancer deaths. melanoma and Hodgkin's disease. Dacarbazine is administered as an intravenous infusion.1
Dacarbazine (DTIC-Dome®) has anti tumor properties, which are metabolically activated. Decarbazine also methylates nucleic acids, while inhibiting DNAAbbreviation for deoxyribonucleic acid. Composed of very long strings of nucleotides, which are abbreviated as A, C, G and T. DNA is the storage form of our genetic material. All of the instructions for the production of proteins are encoded in our DNA. and proteinOne of the four basic types of biomolecule. Proteins are polymers made up of strings of amino acids. Proteins serve many functions in organisms including transport of molecules, structure, cell adhesion and as signaling molecules such as hormones. Many transcription factors, including p53 and Rb are proteins. synthesis.1
The molecular structure below shows the 3D conformer Dacarbazine.
Common side effects include: extreme nausea and vomiting, anorexia, hair loss, and facial flushing. Dacarbazine should not be taken by women who are pregnant and patients should not become pregnant while using this drug, as it may have harmful effects on the developing fetus. Bone marrow depression is the most common toxicity associated with dacarbazine usage. It is important to monitor the levels of white blood cells, red blood cells and platelets. 1
- 1.a. b. c. Chu, E., & DeVita, V. T. (2015). Physicians' cancer chemotherapyTreatment of cancer patients with anticancer drugs. Commonly called 'chemo'. These drugs work by attacking cell growth or division. Often these agents are used in combination to take advantage of their different modes of attack on cell division. drug manual 2015. Burlington, MA: Jones & Bartlett Learning.