Dolasetron

Diagram of the molecular structure of Dolasetron
Brand name: Anzemet®
IUPAC: (3R)-10-oxo-8-azatricyclo[5.3.1.03,8]undec-5-yl 1H-indole-3-carboxylate
FDA approval: Yes
Manufacturer Link
Usage:

Dolasetron mesylate (Anzemet®) is used to the prevent nausea and vomiting associated with cytotoxicHaving the ability to kill a cell. Many chemotherapy drugs are cytotoxic, as is radiation. Cells of our immune system also have the ability to recognize and kill certain cells, including cancer cells. effects of chemotherapyTreatment of cancer patients with anticancer drugs. Commonly called 'chemo'. These drugs work by attacking cell growth or division. Often these agents are used in combination to take advantage of their different modes of attack on cell division.. Dolasetron is administered in pill form.1 In December 2010, the U.S. FDA blocked the use of the injected (intravenous) form of the drug for the prevention of nausea due to chemotherapy.2

Mechanism:

Dolasteron works by blocking the reception of serotonin at 5-HT3 receptors. When these receptors are bound by serotonin, they induce nausea and the vomiting reflex.

The structure below shows the 3D conformer Dolasetron.

 

Side effects:

The most common side effects associated with the use of Anzemet® during chemotherapyTreatment of cancer patients with anticancer drugs. Commonly called 'chemo'. These drugs work by attacking cell growth or division. Often these agents are used in combination to take advantage of their different modes of attack on cell division. regimens are headache, fatigue and diarrhea. The intravenous version of the drug was associated with abnormal heart rhythms.

  • 1. Anzemet.. Prescribing Information. Aventis Pharmaceuticals. September, 2016. [http://www.anzemet.com]
  • 2. https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-abnormal-heart-rhythms-associated-use-anzemet-dolasetron-mesylate