Professor, Departments of Oncology, Urology, Pharmacology and Molecular Sciences, Medicine, Pathology, and RadiationIn cancer biology: A cancer treatment in which high energy beams are used to kill cancer cells. Radiation can also cause genetic damage that can lead to cancer. As an example, skin cancer is believed to be greatly increased by exposure to ultraviolet (UV) radiation from the sun. Oncology and Molecular Radiation Sciences
John's Hopkins School of Medicine
Dr. Nelson's research focuses on epigeneticGene expression can be altered by changes to the DNA and chromatin that do not change the DNA sequence, and are termed epigenetic changes. Two types are: Methylation: where some DNA nucleotides are modified by the addition of a methyl (-CH3) group. Methylation of DNA is associated with the inactivation of that particular region of DNA. Abnormal DNA methylation patterns have been seen in cancer cells. Acetylation: histone proteins around which the DNA is wound are modified by the addition of acetyl (-CH3CHO) groups. This loosens the DNA:histone interaction and is associated with increased gene expression. Understanding the addition and removal of acetyl groups to DNA is an active area of cancer treatment research. changes in prostate cancer. Epigenetics deals with changes that affect the activity of a geneA stretch of DNA that leads to the production of an RNA. The RNA is produced during the process of transcription. This RNA can be used to guide the formation of a protein via translation or can be used directly in the cell. without changing the DNAAbbreviation for deoxyribonucleic acid. Composed of very long strings of nucleotides, which are abbreviated as A, C, G and T. DNA is the storage form of our genetic material. All of the instructions for the production of proteins are encoded in our DNA. sequence of the gene. The changes include DNA methylation and histone acetylation. Dr. Nelson also investigates how these changes can be targeted by cancer drugs.
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