Cancer Treatment Tables

Cancer is treated with a wide variety of drugs.  The following tables contain descriptions of the drugs described on the CancerQuest website.  They are not intended to be comprehensive lists of cancer drugs.  Instead, they provide easy ways to find information on some of the most common cancer treatments.  It is possible for a drug to appear in more than one table.

This section contains the following tables :

 

Chemotherapy Drugs

Below is a table of chemotherapy drugs discussed in this website. To go directly to the page where a particular drug is discussed, click on the name. For an explanation of the type of drug, click on the type of chemotherapy listed. If you have trouble finding a particular drug, go to edit on your browser and use the Find on Page feature.

 

Generic Name Brand Name Type of Chemotherapy
Arabinosylcytosine (ARA-C), Cytarabine Cytosar-U® Antimetabolite
Bleomycin Blenoxane® Other
Busulfan Myleran® GenotoxicRefers to agents that either directly or indirectly cause damage to cellular DNA. Some cancer causing agents, such as benzo-a-pyrene, found in cigarette smoke are genotoxic.Genotoxic agents cause mutations and can lead to changes in proto-oncogenes and tumor suppressor genes. A large number of chemotherapy drugs are also genotoxic. Examples include cisplatin, carboplatin and doxorubicin. These agents kill cancer cells by damaging their DNA, which prevents cell division. The side effects seen with many cancer treatments are a result of their genotoxic effects on normal cells in the body. Agent
Capecitabine Xeloda® Antimetabolite
Carboplatin Paraplatin® Genotoxic Agent
Carmustine Bicnu®, Gliadel® Genotoxic Agent
Chlorambucil Leukeran® Genotoxic Agent
Cisplatin Platinol®, IntraDose®(Cisplatin; Collagen; Epinephrine) Genotoxic Agent
Cyclophosphamide Cytoxan®, Cytoxan®IV, Neosar®, Procytox® Genotoxic Agent
Dacarbazine DTIC-Dome® Genotoxic Agent or
Antimetabolite
Daunorubicin Cerubidine Genotoxic Agent
Docetaxel Taxotere® Spindle Inhibitor
Doxorubicin Adriamycin®, Rubex®, Doxil®, Caelyx®, Myocet™ Genotoxic Agent
Epirubicin Ellence® Genotoxic Agent
Etoposide Etopophos®, Vepesid®, Toposar®, VP-16® Genotoxic Agent
Fludarabine Fludara® Antimetabolite
5-Fluorouracil Adrucil®, Carac®, Fluoroplex®, Efudex®(Injection) Antimetabolite
Gemcitabine Gemzar® Antimetabolite
Hydroxyurea Hydrea® Other
Idarubicin Idamycin PFS® Genotoxic Agent
Ifosfamide Ifex® Genotoxic Agent
Irinotecan Camptosar® Genotoxic Agent
Lomustine CeeNU® Genotoxic Agent
Mechlorethamine Mustargen® Genotoxic Agent
Melphalan Alkeran® Genotoxic Agent
6-Mercaptopurine (6-MP) Purinethol®, Puri-Nethol® Antimetabolite
Methotrexate Rheumatrex®, Trexall®, Mexate®, MTX Antimetabolite
Mitomycin C Mutamycin® Genotoxic Agent
Mitoxantrone Novantrone® Genotoxic Agent
Oxaliplatin Eloxatin® Genotoxic Agent
Paclitaxel Taxol®, Onxol™, Paxene® Spindle Inhibitor
Streptozocin Zanosar® Other
Temozolomide Temodar® Genotoxic Agent
6-Thioguanine Tabloid®, Lanvis® Antimetabolite
Topotecan Hycamtin® Genotoxic Agent
Vinblastine Velban®, Velbe® Spindle Inhibitor
Vincristine Oncovin®, Vincasar PFS®, Vincrex® Spindle Inhibitor
Vindesine Eldisine®, Fildesin® Spindle Inhibitor
Vinorelbine Navelbine® Spindle Inhibitor

More information on these drugs can be found at the FDA Approved Oncology Drugs website and/or the Harrison's Principles of Internal Medicine Online. This site is only available to those with a subscription. A hardcopy version of the book is available from McGraw Hill Publishers

 

Hormonal, Biological, and Antibody-based Treatment Tables

 

Hormonal Treatments

This table lists the hormonal treatments discussed in this website. To go directly to the page where a particular drug is discussed, click on the name. If you have trouble finding a particular drug, go to edit (or press Ctrl+F or Apple+F) on your browser and use the Find on Page feature.

Generic Name Brand Name Type of Hormonal Treatment
Anastrozole Arimidex® Aromatase Inhibitor
Bicalutamide Casodex® Exemestane
Exemestane Aromasin® Aromatase Inhibitor
Flutamide Eulexin® Specific Androgen Receptor Modulator (SARM)
Fulvestrant Faslodex® Estrogen ReceptorA protein located within cells that binds estrogen. The protein:estrogen complex then binds to DNA to increase the transcription of certain genes, and therefore is a type of transcription factor. The estrogen receptor is the target of the anticancer drug tamoxifen. By binding to the estrogen receptor tamoxifen blocks the growth promoting effects of the hormone. May be abbreviated as ER. Down-Regulator
Letrozole Femara® Aromatase Inhibitor
Megestrol Megace® Additional Hormonal Treatments
Raloxifene Evista® Selective Estrogen Receptor Modulator (SERM)
Tamoxifen Nolvadex® Selective Estrogen Receptor Modulator (SERM)
Toremifene Fareston® Selective Estrogen Receptor Modulator (SERM)

 

Biological Treatments
Generic Name Brand Name Type of Drug
Aldesleukin, Interleukin-2 (IL-2) Proleukin® BRM
Alpha InterferonA group of protein messengers produced by cells of the immune system and some other cells. Interferons can help cells to defend themselves against viral infection and are used in the treatment of some cancers to boost the body's ability to eliminate cancer cells. Intron®, Roferon®-A BRM
Imiquimod Aldara® BRM
Lenalidomide Revlimid® BRM

 

Antibody Treatments
Generic Name Brand Name Type of Drug
Alemtuzumab Campath® Antibody
Bevacizumab Avastin® Antibody
Gemtuzumab Mylotarg® Antibody
Ibritumomab Zevalin® Antibody
Rituximab Rituxan®, Mabthera® Antibody
Tositumomab Bexxar® Antibody
Trastuzumab Herceptin® Antibody

More information on these drugs can be found at the FDA Approved Oncology Drugs website and/or the Harrison's Principles of Internal Medicine Online. This site is only available to those with a subscription. A hardcopy version of the book is available from McGraw Hill Publishers

 

Targeted Therapies

The table below lists targeted therapy drugs discussed on this website. To go directly to the page where a particular drug is discussed, click on the name. If you have trouble finding a particular drug, go to edit (or press Ctrl+F) on your browser and use the Find on Page feature.

Generic Name Brand Name Mechanism of Action
Asparaginase Elspar® EnzymeA protein that speeds up the process of chemical reactions in the body without becoming altered in the process. Almost every biological process is driven by the activity of enzymes. Without enzyme catalysts, the complex reactions that build and break down cell parts would not happen at a rate compatible with life. Enzyme names usually describe the reaction that is being catalyzed and all of them end in -ase. Activator
Bevacizumab Avastin® AngiogenesisThe formation of blood vessels. This process is required for a tumor to grow past a small size since the blood delivers nutrients to the cells in the tumor mass. Inhibitors
Bexarotene Targretin® Drug that Affects a Molecular Receptor
Bortezomib Velcade® Proteosome Inhibitor
Denileukin diftitox ONTAK® Drug that Affects a Molecular Receptor
Gefitinib Iressa® KinaseAn enzyme that adds phosphate groups to another molecule. Many key proteins controlling gene expression are kinase targets. Addition of a phosphate group to a protein can alter the activity of the protein and are often used as molecular on/off switches. For example, the retinoblastoma tumor suppressor gene is 'off' when phosphate groups are added to the protein at specific locations. Removal of the phosphate groups turns the protein 'on'. Enzymes that remove phosphate groups are known as phosphatases. Note that all enzymes, regardless of function, end in ASE Inhibitor
Imatinib Mesylate Gleevec®, Glivec® Kinase Inhibitor
Lapatinib Tykerb® Kinase Inhibitor
Sorafenib Nexavar® Kinase Inhibitor
Sunitinib Sutent® Kinase Inhibitor

More information on these drugs can be found at the FDA Approved Over the Counter and Prescription Drugs website and/or the Harrison's Principles of Internal Medicine Online. This site is only available to those with a subscription. A hardcopy version of the book is available from McGraw Hill Publishers

More information on this topic may be found in Chapter 16 of The Biology of Cancer by Robert A. Weinberg.

 

Complementary and Alternative Medicine (CAM)

CAM Classification

CAM Therapy

Animal Derived Coenzyme Q10, Shark Cartilage
Mind-Body Techniques Hypnosis, Prayer, Spirituality, Support Groups, Yoga, Tai Chi
Phytochemicals Anthocyanin, Cannabis and Hemp Oil, Curcumin, EGCG, Lycopene, Phytoestrogens, Pycnogenol, Resveratrol, Selenium, Essiac®, Flor-Essence®
Product / Treatment Plan Controlled Amino AcidA monomer building block used to build proteins. There are many amino acids but only about twenty different kinds are found in most proteins. Therapy, Essiac®, Flor-Essence®, Homeopathy
Man-made chemicals DCA

 

Biological Process Affected

CAM Therapy

Angiogenesis Curcumin, DCA, EGCG, Shark Cartilage, Resveratrol
ApoptosisAlso called programmed cell death. Apoptosis is a natural process that occurs throughout the lives of almost all animals and plants. The death of the cells is a carefully controlled process that does not generate any inflammation. Anthocyanin, Curcumin, DCA, EGCG, Lycopene, Resveratrol, Selenium
InflammationA reaction to tissue damage or invasion. Small blood vessels become leaky, leading to redness and swelling. Cells of the immune system migrate to the area and can release chemicals and proteins that cause damage to the structures/cells nearby. Anthocyanin, Pycnogenol
MetabolismThe sum of all reactions in a cell or animal. Processes that lead to the creation of biomolecules such as proteins and nucleic acids are termed anabolic pathways. Processes in which biomolecules are broken down, such as the digestion of foods, are termed catabolic. Metabolism is a term that encompasses both sets of processes. DCA
Metastasis Curcumin, Resveratrol
Oxidation
(i.e. Antioxidants)
Anthocyanin, Curcumin, EGCG, Essiac®, Flor-Essence®, Lycopene, Phytoestrogens, Pycnogenol
ProliferationRefers to cell division. The proliferation rate is an indicator of how quickly a tumor is growing. The proliferation rate may be represented as a percentage, showing what fraction of the cells are actively involved in the division process. Anthocyanin, Coenzyme Q10, Curcumin, EGCG, Selenium